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Adooq Products cited in reputable papers
| Catalog No. | Product Name | Product Information |
|---|---|---|
A11230 |
PF 429242 |
PF 429242 is a reversible, competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease.
|
A13448 |
CZC-25146 |
CZC-25146 is a potent and selective LRRK2 inhibitor. CZC-25146 prevents mutant LRRK2-induced injury of cultured rodent and human neurons with mid-nanomolar potency.
|
A14180 |
AM095 free base |
AM095 is a novel, potent and orally bioavailable antagonist of lysophosphatidic acid type 1 receptor (LPA1) with IC50 values of 0.73 and 0.98 μM for mouse or recombinant human LPA1, respectively
|
A14075 |
Amyloid b-Peptide (1-42) (human) |
Amyloid beta (Aβ or Abeta) is a peptide of 36-C43 amino acids that is processed from the Amyloid precursor protein. Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.
|
A14318 |
SU9516 |
SU9516 is a potent, selective cdk2 inhibitor. It inhibits pRb phosphorylation causing enhanced pRB/E2F complex formation and induces G1 and G2-M cell cycle arrest.
|
A14415 |
Debio-1347 (CH5183284) |
Debio-1347 is an orally bioavailable inhibitor of the fibroblast growth factor receptor subtypes 1 (FGFR-1), 2 (FGFR-2) and 3 (FGFR-3), with potential antineoplastic activity.
|
A14362 |
VcMMAE |
VcMMAE is an antibody-drug conjugate (ADC) with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc).
|
A14089 |
CM 346 (Afobazole) |
CM 346 is an anxiolytic drug, produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions.
|
A13854 |
A-841720 |
A 841720 is a potent, non-competitive mGluR-1 antagonist that displays 34-fold selectivity over mGluR-5 (IC50 values are 10 and 342 nM respectively).
|
A13657 |
CL 316243 disodium salt |
CL 316243 disodium salt, a beta-3 adrenergic agonist, was developed as an anti-obesity and diabetes drug, and causes rapid decreases in blood glucose levels in mice.
|
A13671 |
Z-360 calcium salt (Nastorazepide calcium salt) |
Z-360 is a selective, orally available, 1,5-benzodiazepine-derivative gastrin/cholecystokinin 2 (CCK-2) receptor antagonist with potential antineoplastic activity.
|
A13548 |
PF-3635659 |
PF-3635659 is a potent muscarinic M(3) receptor antagonist.
|
A13553 |
Dilmapimod |
Dilmapimod is p38 MAPK inhibitor.
|
A13442 |
A 943931 2HCl |
A 943931 2HCl is a potent and selective histamine H4 receptor antagonist (pKi values are 7.15 and 8.12 at human and rat receptors respectively).
|
A15366 |
ZM 449829 |
JAK3 Inhibitor V is a potent, selective inhibitor of JAK3 (Janus tyrosine kinase 3) which binds competitively to the JAK3 ATP site.
|
| Catalog No. | Product Name | Product Information |
|---|---|---|
A11293 |
AR-C155858 |
AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10.
|
A12742 |
BAY 1000394 (Roniciclib) |
BAY 1000394 is an orally bioavailable cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity.
|
A13192 |
IWP-3 |
IWP-3 is an inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC₅₀ = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC₅₀ = 1.2 μM).
|
A13041 |
PST-2744 (Istaroxime) |
Istaroxime is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase).
|
A15263 |
Toceranib phosphate |
Toceranib phosphate is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFRβ.
|
A15264 |
Toll-like receptor modulator |
Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system.
|
A15265 |
Toremifene |
Toremifene is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis.
|
A15266 |
Trenbolone |
Trenbolone is a steroid used by veterinarians on livestock to increase muscle growth and appetite.
|
A15267 |
Tyrosine kinase inhibitor |
Tyrosine-kinase inhibitor is a pharmaceutical drug that inhibits tyrosine kinases. Tyrosine kinases are enzymes responsible for the activation of many proteins by signal transduction cascades.
|
A15268 |
Umeclidinium bromide |
Umeclidinium bromide(GSK573719A) is a muscarinic receptor antagonist which is useful in treatment of chronic obstructive pulmonary disease (COPD).
|
A15269 |
VAL-083 |
VAL-083 is a bi-functional alkylating agent; inhibit U251 and SF188 cell growth in monolayer better than TMZ and caused apoptosis.
|
A15270 |
Valaciclovir |
Valacyclovir is an antiviral drug used in the management of herpes simplex, herpes zoster, and herpes B.
|
A15271 |
Vandetanib HCl |
Vandetanib is a potent inhibitor of VEGFR2 with IC50 of 40 nM.
|
A15272 |
Vandetanib trifluoroacetate |
Vandetanib is a potent inhibitor of VEGFR2 with IC50 of 40 nM.
|
A15273 |
Vc-MMAD |
Vc-MMAD consists the ADCs linker(Val-Cit) and potent tubulin inhibitor (MMAD), Vc-MMAD is an antibody drug conjugate.
|
A15274 |
VD2-D3 |
VD2-D3 is a deuterated form of vitamin D.
|
A15276 |
Vicriviroc maleate |
Vicriviroc maleate is a CCR5 antagonist with IC50 of 0.91 nM in clinical development for the treatment of HIV-1.
|
A15277 |
Vigabatrin |
Vigabatrin is a structural analog of the inhibitory neurotransmitter ??-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase.
|
A15278 |
Vitamin D4 |
Vitamin D4 is the active analogue of Vitamin D.
|
A15279 |
VO-Ohpic trihydrate |
VO-Ohpic trihydrate is an inhibitor of PTEN (phosphatase and tensin homologue deleted on chromosome 10).
|
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